Dr. Siddharth Srivastava is an Assistant Professor of Neurology at Harvard Medical School and a pediatric neurologist at Boston Children’s Hospital specializing in neurogenetics and neurodevelopmental disabilities. His overall mission is to improve the lives of children with neurogenetic and neurodevelopmental disorders by translating scientific discoveries into meaningful clinical practice changes.
His research focuses on investigating genetic causes of intellectual disability (ID) and cerebral palsy (CP), particularly developmental synaptopathies. His long-term goal is to improve understanding of the phenotypic complexity and basis of these disorders in order to develop novel outcome measures and targeted treatments. He leverages a multi-model approach encompassing (1) gene discovery and genotype-phenotype associations (2) neurodevelopmental/natural history phenotyping (3) biomarker identification (4) precision medicine trials. The synaptic disorders he is currently focused on include Phelan McDermid Syndrome, PTEN Hamartoma Tumor Syndrome, and Kleefstra Syndrome.
At Boston Children’s Hospital, he provides care to children in a variety of neurodevelopmental and neurogenetics clinics. He runs the Developmental Neurogenetics Program, which specializes in the diagnosis and management of genetic disorders associated with neurodevelopmental disabilities. The goals of this program include optimizing long-term neurodevelopmental outcomes and coordinating specialty care across multiple disciplines. Within this program, some of the specific genetic disorders he follows include Phelan McDermid Syndrome, PTEN Hamartoma Tumor Syndrome, and Kleefstra Syndrome. He also evaluates and treats patients in the Cerebral Palsy Program, where one of his goals is to diagnose genetic disorders presenting as cerebral palsy.
cerebral palsy.
